RNAi Screening Libraries
Cayman Chemical Humn ndrogen Receptr Repor 96
A fluoroquinolone antibiotic active against a variety of Gram-positive and Gram-negative bacteria in vitro including S. aureus L. monocytogenes P. aeruginosa Legionella N. gonorrhoeae and H. pylori (MIC50s 0.004-1 Ug/ml) active against clinical isolates of Bacteroides Fusobacterium Eubacterium Actinomyces Peptococcus Peptostreptococcus and Streptococcus in vitro (MIC50s 0.5-2 Ug/ml) inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s 13.5 and 5.76 Ug/ml respectively) reduces mortality in mouse models of intraperitoneal E. coli P. vulgaris K. pneumoniae P. aeruginosa and S. aureus infection (ED90-100s 1-5 2.5-5 5-10 20-40 and 80 mg/kg respectively) prevents mortality in a mouse model of subcutaneous S. typhimurium infection at 10 mg/kg
Cayman Chemical Humn RetInoIc ACD Receptr 384
Non-denaturing detergent used to solubilize and reconstitute membrane-bound proteins characterized by a high critical micelle concentration (0.7 ) which facilitates ready removal from final protein extracts
Cayman Chemical Humn RetInoIc ACD Receptr 384
Non-denaturing detergent used to solubilize and reconstitute membrane-bound proteins characterized by a high critical micelle concentration (0.7 ) which facilitates ready removal from final protein extracts
Cayman Chemical Humn ProgSTRon Receptr R 384
A potent reversible ATP-competitive and selective inhibitor of the Src family of protein tyrosine kinases p56lck (IC50 5 nM) p59fynT (IC50 6 nM) Hck (IC50 20 nM)
Cayman Chemical EP4 Receptr ntagonIst 1 10mg
A cGAS inhibitor (IC50 0.24 UM) reduces DNA-induced dimerization of IRF3 in THP-1 cells decreases IFN-stimulatory DNA-induced production of IFN-B in THP-1 cells at 10 30 and 100 UM
Cayman Chemical EP4 Receptr ntagonIst 1 5mg
A diterpene with antiulcerogenic activity decreases gastric mucosal MDA levels and ulcer area in a rat model of pyloric ligation-induced ulcers
Cayman Chemical Humn Growth Hormon Receptr 96
A byproduct formed during SPPS of aspartic acid-containing peptides
Cayman Chemical Estrogen Receptr BIoasy 96Wel
A BD2 bromodomain inhibitor inhibits BD2 in BRD2 BRD3 and BRD4 (IC50s 0.08 0.05 and 0.02 UM respectively) and is selective for BD2 over BD1 (IC50s 3.76 2.34 and 1.16 UM for BRD2 BRD3 and BRD4 respectively) as well as CREBBP and p300 (IC50s 50 UM for both) decreases levels of the mRNAs encoding IL-6 and VCAM-1 in primary synovial fibroblasts isolated from patients with rheumatoid arthritis at 10 and 30 UM It prevents LPS-induced increases in IL-6 and Ifn-Y serum levels in a mouse model of LPS-induced endotoxemia at 75 mg/kg inhibits collagen-induced increases in ankle and knee diameter cartilage damage the ankle tissue levels of mRNAs encoding IL-1B Mmp-3 Mmp-13 and Rankl and ankle joint protein levels of IL-6 and VCAM-1 in a rat model of collagen-induced rheumatoid arthritis at 25 50 and 75 mg/kg twice per day improves gait and mobility and reverses body w8 loss as well as decreases the number of spinal cord inflammatory foci and apoptotic cells
Cayman Chemical MelnocortIn3 Receptr Rever 1ea
An MC4R antagonist selectively inhibits [Nle4D-Phe7]-a-MSH binding to recombinant human MC4R over MC1R and MC3R (IC50s 11.63 >10000 and 1115 nM respectively) inhibits a-MSH-induced cAMP production in COS-1 cells expressing human MC4R from 0.1-100 UM reduces stress-induced decreases in the time spent in the light area of the light/dark exploration test in mice reverses restraint stress-induced decreases in food intake in rats
Cayman Chemical RabbIt ProgSTRon Receptr 96Wel
A flavonoid with diverse biological activities inhibits mushroom tyrosinase activity (IC50 13.64 UM) decreases cytotoxicity induced by IHNV in FSP cells and VHSV in CHSE-214 cells (EC50s 178.2 and 197.3 UM respectively) decreases eosinophil macrophage and lymphocyte infiltration and reduces the levels of TNF-a IL-5 IL-13 and CCL11 in BALF as well as inhibits methacholine-induced bronchoconstriction in a mouse model of ovalbumin-induced asthma at 40 Ug/kg
Cayman Chemical Tol-LIke Receptr 8 Monclon 1ea
Peptide contains a lysine at position 20 which is a substrate or acceptor peptide for the lysine methyltransferases KMT5A (SET8) and KMT5B (SUV4-20H1)
Cayman Chemical Glucagon Receptr ntagonIst 5mg
A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC50 3 3 UM) demonstrates antibacterial activity against E coli P aeruginosa and S enterica (MICs range from 10-80 UM)
